import matplotlib.pyplot as plt
from matplotlib.patches import Patch
import numpy as np
from scipy.interpolate import make_interp_spline

# 1. RLM data
x = [0, 0.05, 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 
     0.55, 0.6, 0.65, 0.7, 0.75, 0.8, 0.85, 0.9, 0.95, 1]

# Frequencies in %
y = [1.74, 16.79, 11.17, 9.75, 6.23, 6.63, 5.06, 4.89, 3.88, 2.95, 3.56, 
     2.67, 3.07, 2.63, 2.87, 3.20, 3.72, 3.80, 3.48, 1.82, 0.08]

# 2. Curve smoothing (Spline)
x_smooth = np.linspace(min(x), max(x), 300)
spl = make_interp_spline(x, y, k=3)
y_smooth = spl(x_smooth)
y_smooth = [val if val > 0 else 0 for val in y_smooth] 

# 3. Define colors (RLM Traffic Light - Reverse: Left is better)
colors = []
for val in x:
    # High Stability (Low probability of instability)
    if val <= 0.3:
        colors.append('green')
    # High Instability (> 0.7) - More common in rats than humans
    elif val >= 0.7:
        colors.append('firebrick')
    # Intermediate
    else:
        colors.append('gold')

# 4. Create the chart
plt.figure(figsize=(7, 6))

# A. Bars
plt.bar(x, y, width=0.04, color=colors, edgecolor='black', alpha=0.7, label='Data Frequency')

# 5. Tags and Titles
plt.xlabel('RLM Probability (0=Stable, 1=Unstable)', fontsize=12)
plt.ylabel('% Frequency', fontsize=12)
plt.title('Rat Liver Microsomal (RLM) Stability Prediction', fontsize=14)

# Axle settings
plt.xticks(np.arange(0, 1.1, 0.1))
plt.xlim(-0.05, 1.05)
plt.ylim(0, 18)

# 6. Vertical Legend (ON THE RIGHT)
legend_elements = [
    Patch(facecolor='green', edgecolor='black', alpha=0.7, label='Stable in Rat (Score < 0.3)'),
    Patch(facecolor='gold', edgecolor='black', alpha=0.7, label='Moderate / Variable (0.3 - 0.7)'),
    Patch(facecolor='firebrick', edgecolor='black', alpha=0.7, label='Unstable in Rat (Score > 0.7)')
]

plt.legend(handles=legend_elements, loc='upper right', ncol=1, framealpha=0.9)

plt.grid(axis='y', linestyle='--', alpha=0.5)
plt.tight_layout()

plt.show()